Cerebellar dysfunction in progressive supranuclear palsy: A transcranial magnetic stimulation study
Identifieur interne : 001E10 ( Main/Exploration ); précédent : 001E09; suivant : 001E11Cerebellar dysfunction in progressive supranuclear palsy: A transcranial magnetic stimulation study
Auteurs : Yuichiro Shirota [Japon] ; Masashi Hamada [Japon] ; Ritsuko Hanajima [Japon] ; Yasuo Terao [Japon] ; Hideyuki Matsumoto [Japon] ; Shinya Ohminami [Japon] ; Shoji Tsuji [Japon] ; Yoshikazu Ugawa [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Cerebellar Diseases (etiology), Cerebellum, Dysfunction, Electroencephalography (methods), Electromyography (methods), Evoked Potentials, Motor (physiology), Female, Hand (innervation), Humans, Male, Middle Aged, Muscle, Skeletal (physiopathology), Nervous system diseases, Reaction Time (physiology), Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric, Supranuclear Palsy, Progressive (complications), Supranuclear ophthalmoplegia, Time Factors, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, cerebellum, progressive supranuclear palsy, transcranial magnetic stimulation.
- MESH :
- complications : Supranuclear Palsy, Progressive.
- etiology : Cerebellar Diseases.
- innervation : Hand.
- methods : Electroencephalography, Electromyography.
- physiology : Evoked Potentials, Motor, Reaction Time.
- physiopathology : Muscle, Skeletal.
- Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric, Time Factors, Transcranial Magnetic Stimulation.
Abstract
Progressive supranuclear palsy (PSP) rarely shows cerebellar signs and symptoms even though the cerebellar dentate nuclei are involved pathologically. This study evaluates cerebellar function using transcranial magnetic stimulation (TMS) to determine whether subclinical cerebellar involvement is present in PSP patients. We studied 11 patients with PSP, 11 patients with Parkinson's disease (PD), and 10 age‐matched controls. Patients were examined with their usual medications and in their relative on state. Motor evoked potentials (MEPs) were recorded from the hand muscle. Cerebellar function was evaluated using suppressive effects of TMS over the cerebellum on MEPs elicited by TMS over the contralateral motor cortex, which we call cerebellar inhibition (CBI). Interstimulus intervals (ISIs) of 4 to 8 ms were used, and the time course of CBI was analyzed. The CBI was reduced in PSP patients. By contrast, the CBI was normal in PD patients in their on state. Although the CBI in their off state should be examined in future studies, the results described herein suggest that Purkinje cells or the dentato–thalamo–cortical pathway assessed by CBI is involved in PSP. Our results are compatible with the pathological findings showing severe dentate nucleus degeneration in PSP patients. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23298
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2413">2413</biblScope><biblScope unit="page" to="2419">2419</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B2D99307678FDE36568C5FA73C900893F508B887</idno><idno type="DOI">10.1002/mds.23298</idno><idno type="ArticleID">MDS23298</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Cerebellar Diseases (etiology)</term><term>Cerebellum</term><term>Dysfunction</term><term>Electroencephalography (methods)</term><term>Electromyography (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Hand (innervation)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle, Skeletal (physiopathology)</term><term>Nervous system diseases</term><term>Reaction Time (physiology)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear ophthalmoplegia</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>cerebellum</term><term>progressive supranuclear palsy</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cerebellar Diseases</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electroencephalography</term><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Statistics, Nonparametric</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cervelet</term><term>Ophtalmoplégie supranucléaire</term><term>Pathologie du système nerveux</term><term>Stimulation magnétique transcrânienne</term><term>Trouble fonctionnel</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) rarely shows cerebellar signs and symptoms even though the cerebellar dentate nuclei are involved pathologically. This study evaluates cerebellar function using transcranial magnetic stimulation (TMS) to determine whether subclinical cerebellar involvement is present in PSP patients. We studied 11 patients with PSP, 11 patients with Parkinson's disease (PD), and 10 age‐matched controls. Patients were examined with their usual medications and in their relative on state. Motor evoked potentials (MEPs) were recorded from the hand muscle. Cerebellar function was evaluated using suppressive effects of TMS over the cerebellum on MEPs elicited by TMS over the contralateral motor cortex, which we call cerebellar inhibition (CBI). Interstimulus intervals (ISIs) of 4 to 8 ms were used, and the time course of CBI was analyzed. The CBI was reduced in PSP patients. By contrast, the CBI was normal in PD patients in their on state. Although the CBI in their off state should be examined in future studies, the results described herein suggest that Purkinje cells or the dentato–thalamo–cortical pathway assessed by CBI is involved in PSP. Our results are compatible with the pathological findings showing severe dentate nucleus degeneration in PSP patients. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Shirota, Yuichiro" sort="Shirota, Yuichiro" uniqKey="Shirota Y" first="Yuichiro" last="Shirota">Yuichiro Shirota</name></noRegion><name sortKey="Hamada, Masashi" sort="Hamada, Masashi" uniqKey="Hamada M" first="Masashi" last="Hamada">Masashi Hamada</name><name sortKey="Hanajima, Ritsuko" sort="Hanajima, Ritsuko" uniqKey="Hanajima R" first="Ritsuko" last="Hanajima">Ritsuko Hanajima</name><name sortKey="Matsumoto, Hideyuki" sort="Matsumoto, Hideyuki" uniqKey="Matsumoto H" first="Hideyuki" last="Matsumoto">Hideyuki Matsumoto</name><name sortKey="Ohminami, Shinya" sort="Ohminami, Shinya" uniqKey="Ohminami S" first="Shinya" last="Ohminami">Shinya Ohminami</name><name sortKey="Terao, Yasuo" sort="Terao, Yasuo" uniqKey="Terao Y" first="Yasuo" last="Terao">Yasuo Terao</name><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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